SCIENTIFIC RESEARCHER

Employment: 

Research laboratory at Department of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove

Working position: 

Academic and research staff

Education and qualification:

2015 - 2020 

Charles University, Faculty of Pharmacy in Hradec Králové, doctoral study program Bioanalytical chemistry

dissertation thesis: The application of HPLC and UHPLC-MS/MS techniques in clinical research

supervisor: assoc. prof. PharmDr. Ludmila Matysová, Ph.D.

co-supervior: assoc. prof. RNDr. Lenka Kujovská Krčmová, Ph.D.

2010 - 2015 

Charles University, Faculty of Pharmacy in Hradec Králové, study program Pharmacy

diploma thesis: Development of HPLC method for determination of vancomycin in clinical research

2002 - 2010 

Secondary school - Secondary Grammar School, Český Těšín

Work Experience:

2019 - 2023

Researcher, Research laboratory at Department of Clinical Biochemistry and Diagnostics, University Hospital Hradec Králové, Czech Republic 

2015 - 2019

Teaching, selected subjects at the Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University

2015 - 2020

Postgraduate student, Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University

2015 

Present junior researcher, Research laboratory of Department of Clinical Biochemistry and Diagnostics, University Hospital Hradec Králové

Courses:

2018 

19. School of mass spectrometry

2017 

18. School of mass spectrometry

2016 

Mass spectrometry in organic analysis

Total publications: 15, H-Index 3, Sum of cit.: 45, Sum of IF: 50.2

(update 12/2022)

Publications:

2024

15. Carazo, A., Hrubsa, M., Konecny, L., Gunaseelan, C., Fadraersada, J., Skorepa, P., Paclikova, M., Musil, F., Karlickova, J., Javorska, L., Matousova, K., Kujovska Krcmova, L., Smahelova, A., Blaha, V., Mladenka, P., Correlations among different platelet aggregation pathways in a group of healthy volunteers, Platelets, 2024, In Press, DOI: 10.1080/09537104.2024.2336093

14. Kujovska Krcmova, L., Javorska, L., Matousova, K., Smahel, P., Skala, M., Kopecky, M., Suwanvecho, Ch., Privratska, N., Turonova, D., Melichar, B., Evaluation of inflammatory biomarkers and vitamins in hospitalized patients with SARS-CoV-2 infection and post-COVID syndrome, Clinical Chemistry and Laboratory Medicine, 2024, DOI: 10.1515/cclm-2023-1297

13. Fadraersada, J., Alva‑Gallegos, R., Skorepa, P., Musil, F., Javorska, L., Matousova, K., Kujovska Krcmova, L., Paclikova, M., Carazo, A., Blaha, V., Mladenka, P., Head‑to‑head ex vivo comparison of clinically used direct anticoagulant drugs, Naunyn-Schmiedeberg's Archives of Pharmacology, 2024, In Press, DOI: 10.1007/s00210-023-02891-x

12. Mrstna, K., Matousova, K., Kujovska Krcmova, L., Carazo, A., Pourova, J., Mladenka, P., Matysova, L., Svec, F., Analysis of vitamin K1 and major K2 variants in rat/human serum and lipoprotein fractions by a rapid, simple, and sensitive UHPLC-MS/MS method, Journal of Chromatography A, 2024, 464548, DOI: 10.1016/j.chroma.2023.464548

2023

11. Chocholous, P., Matousova, K., Satinsky, D., Kujovska Krcmova, L., Sklenarova, H., Longevity and other practical benefits of monolithic silica columns in the analysis of samples with complex matrices, Journal of Separation Science, 2023, 2300448, DOI: 10.1002/jssc.202300448

10. Kujovska Krcmova, L., Matousova, K., Javorska, L., Smahel, P., Skala, M., Koblizek, V., Skop, J., Turonova, D., Gancarcikova, M., Melichar, B., Neopterin and kynurenice in serum and urine as prognostic biomarkers in hospitalized patients with delta and omicron variant SARS-CoV-2 infection, Clinical Chemistry and Laboratory Medicine, 2023, 61(11), 2053-2064, DOI: 10.1515/cclm-2023-0381

9. Konecny, L., Hrubsa, M., Karlickova, Carazo, A., Javorska, L., Matousova, K., Kujovska Krcmova, L., Smahelova, A., Blaha, V., Blaha, M., Mladenka, P., The Impact of Convertase Subtilisin/Kexin Type 9 Monoclonal Antibodies with and without Apheresis on Platelet Aggregation in Familial Hypercholesterolemia, Cardiovascular Drugs and Therapy, 2023, DOI: 10.1007/s10557-023-07455-y

8. Konecny, L., Hrubsa, M., Karlickova, J., Carazo, A., Javorska, L., Matousova, K., Kujovska Krcmova, L., Smahelova, A., Blaha, V., Blaha, M., Mladenka, P., The Effect of 4-Methylcatechol on Platelets in Familial Hypercholesterolemic Patients Treated with Lipid Apheresis and/or Proprotein Convertase Subtilisin Kexin 9 Monoclonal Antibodies, Nutrients, 2023, 15, 1842, DOI: 10.3390/nu15081842

7. Spisarova, M., Melichar, B., Juranova, J., Zemankova, A., Adam, T., Matousova, K., Javorska, L., Kujovska Krcmova, L., Turonova, D., Studentova, H., Biomarkers of Inflammation and Progression During Immunotherapy in Patients with Metastatic Renal Cell Carcinoma, In Vivo, 2023, 37, 393-399, DOI: 10.21873/invivo.13091

6. Mrstna, K., Matousova, K., Matous, P., Matysova, L., Svec, F., Snejdrova, E., Kujovska Krcmova, L., Analysis of terbinafine in PLGA-based drug delivery systems by a fast and sensitive UHPLC-DAD method, Analytical Methods, 2023, 15, 2823-2832, DOI: 10.1039/D3AY00506B

2022

5. Hrubsa, M., Konecny, L., Paclikova, M., Parvin, S., Skorepa, P., Musil, F., Karlickova, J., Javorska, L., Matousova, K., Kujovska Krcmova, L., Carazo, A., Smahelova, A., Blaha, V., Mladenka, P., The Antiplatelet Effect of 4-Methylcatechol in a Real Population Sample and Determination of the Mechanism of Action, Nutrients, 2022, 14. DOI: 10.3390/xxxx

4. Carazo, A., Hrubsa, M., Konecny, L., Skorepa, P., Paclikova, M., Musil, F., Karlickova, J., Javorska, L., Matousova, K., Kujovska Krcmova, L., Parvidn, S., Smahelova, A., Blaha, V., Mladenka, P., Sex-Related Differences in Platelet Aggregation: A Literature Review Supplemented with Local Data from a Group of Generally Healthy Individuals, Seminars in Thrombosis & Hemostasis, 2022, DOI: 10.1055/s-0042-1756703

3. Hrubsa, M., Siatka, T., Nejmanova, I., Voprsalova, M., Kujovska Krcmova, L., Matousova, K., Javorska, L., Macakova, K., Mercolini, L., Remião, F., Maťus, M., Mladenka, P., Biological properties of vitamins of the B-complex, part 1 – vitamins B1, B2, B3 and B5, Nutrients, 2022, 14, 484

2021

2. Kaska, M., Havel, E., Javorska, L., Matousova, K., Paral, J., Chobola, M., Safranek, P., Bezouska, J., Kujovska Krcmova, L., Can early postoperative parenteral nutrition have some impact on postoperative inflammatory response intensity?, Clinical Nutrition Espen, 2021, 45, p. 150-154. DOI: 10.1016/j.clnesp.2021.07.022

2019

1. Kucerova K., Kujovska Krcmova L., Mikanova Z., Matysova L., Melichar B., Svec F., Determination of urinary retinol and kreatinin as an early sensitive marker of renul dysfunction, Journal of Chromatography A, 2019, 1607, a. n. 460390

Internships:

2019

Faculty of Chemistry, Jagiellonian University in Krakow (1 month)