SCIENTIFIC RESEARCHER

Employment: 

Research laboratory at Department of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove

Working position: 

Academic and research staff

Education and qualification:

2013 - 2019 

Charles University, Faculty of Pharmacy in Hradec Kralove

Doctoral study program: Bioanalytical chemistry

thesis: Development of bioanalytical methods for the determination of diagnostic markers and drugs

using chromatographic techniques

2011 - 2013 

Charles University in Prague, Faculty of Pharmacy in Hradec Kralove

Master's degree program: Healthcare Bioanalytics, branch: Specialist in Laboratory Methods

2008 - 2011 

Charles University in Prague, Faculty of Pharmacy in Hradec Králové

Bachelor´s degree program: Healthcare Bioanalytics

Grant projects:

Member of research teams: AZV MZ CR NV 18-03-00130 (2018-2021), 17-31754A a 17-29241A (2017-2020);

University Hospital Internal Grant HK 00179906 (2017, 2018, 2019); GAUK 677012/C/2012; 

Participation on grant: IGA MZ CR NT14265-3/2013 (2012-2015)

Total publications: 21, H-Index 3, Sum of IF= 13, Sum of cit.: 33, Sum of cit. without self-citation: 32

(update 6/2023)

First author: 2

Publications:

2024

21. Carazo, A., Hrubsa, M., Konecny, L., Gunaseelan, C., Fadraersada, J., Skorepa, P., Paclikova, M., Musil, F., Karlickova, J., Javorska, L., Matousova, K., Kujovska Krcmova, L., Smahelova, A., Blaha, V., Mladenka, P., Correlations among different platelet aggregation pathways in a group of healthy volunteers, Platelets, 2024, In Press, DOI: 10.1080/09537104.2024.2336093

20. Kujovska Krcmova, L., Javorska, L., Matousova, K., Smahel, P., Skala, M., Kopecky, M., Suwanvecho, Ch., Privratska, N., Turonova, D., Melichar, B., Evaluation of inflammatory biomarkers and vitamins in hospitalized patients with SARS-CoV-2 infection and post-COVID syndrome, Clinical Chemistry and Laboratory Medicine, 2024, DOI: 10.1515/cclm-2023-1297

19. Fadraersada, J., Alva‑Gallegos, R., Skorepa, P., Musil, F., Javorska, L., Matousova, K., Kujovska Krcmova, L., Paclikova, M., Carazo, A., Blaha, V., Mladenka, P., Head‑to‑head ex vivo comparison of clinically used direct anticoagulant drugs, Naunyn-Schmiedeberg's Archives of Pharmacology, 2024, In Press, DOI: 10.1007/s00210-023-02891-x

2023

18. Kujovska Krcmova, L., Matousova, K., Javorska, L., Smahel, P., Skala, M., Koblizek, V., Skop, J., Turonova, D., Gancarcikova, M., Melichar, B., Neopterin and kynurenice in serum and urine as prognostic biomarkers in hospitalized patients with delta and omicron variant SARS-CoV-2 infection, Clinical Chemistry and Laboratory Medicine, 2023, 61(11), 2053-2064, DOI: 10.1515/cclm-2023-0381

17. Konecny, L., Hrubsa, M., Karlickova, Carazo, A., Javorska, L., Matousova, K., Kujovska Krcmova, L., Smahelova, A., Blaha, V., Blaha, M., Mladenka, P., The Impact of Convertase Subtilisin/Kexin Type 9 Monoclonal Antibodies with and without Apheresis on Platelet Aggregation in Familial Hypercholesterolemia, Cardiovascular Drugs and Therapy, 2023, DOI: 10.1007/s10557-023-07455-y

16. Konecny, L., Hrubsa, M., Karlickova, J., Carazo, A., Javorska, L., Matousova, K., Kujovska Krcmova, L., Smahelova, A., Blaha, V., Blaha, M., Mladenka, P., The Effect of 4-Methylcatechol on Platelets in Familial Hypercholesterolemic Patients Treated with Lipid Apheresis and/or Proprotein Convertase Subtilisin Kexin 9 Monoclonal Antibodies, Nutrients, 2023, 15, 1842, DOI: 10.3390/nu15081842

15. Spisarova, M., Melichar, B., Juranova, J., Zemankova, A., Adam, T., Matousova, K., Javorska, L., Kujovska Krcmova, L., Turonova, D., Studentova, H., Biomarkers of Inflammation and Progression During Immunotherapy in Patients with Metastatic Renal Cell Carcinoma, In Vivo, 2023, 37, 393-399, DOI: 10.21873/invivo.13091

2022

14. Hrubsa, M., Konecny, L., Paclikova, M., Parvin, S., Skorepa, P., Musil, F., Karlickova, J., Javorska, L., Matousova, K., Kujovska Krcmova, L., Carazo, A., Smahelova, A., Blaha, V., Mladenka, P., The Antiplatelet Effect of 4-Methylcatechol in a Real Population Sample and Determination of the Mechanism of Action, Nutrients, 2022, 14. DOI: 10.3390/xxxx

13. Carazo, A., Hrubsa, M., Konecny, L., Skorepa, P., Paclikova, M., Musil, F., Karlickova, J., Javorska, L., Matousova, K., Kujovska Krcmova, L., Parvidn, S., Smahelova, A., Blaha, V., Mladenka, P., Sex-Related Differences in Platelet Aggregation: A Literature Review Supplemented with Local Data from a Group of Generally Healthy Individuals, Seminars in Thrombosis & Hemostasis, 2022, DOI: 10.1055/s-0042-1756703

12. Hrubsa, M., Siatka, T., Nejmanova, I., Voprsalova, M., Kujovska Krcmova, L., Matousova, K., Javorska, L., Macakova, K., Mercolini, L., Remião, F., Maťus, M., Mladenka, P., Biological properties of vitamins of the B-complex, part 1 – vitamins B1, B2, B3 and B5, Nutrients, 2022, 14, 484

2021

11. Kaska, M., Havel, E., Javorska, L., Matousova, K., Paral, J., Chobola, M., Safranek, P., Bezouska, J., Kujovska Krcmova, L., Can early postoperative parenteral nutrition have some impact on postoperative inflammatory response intensity?, Clinical Nutrition Espen, 2021, 45, p. 150-154. DOI: 10.1016/j.clnesp.2021.07.022

10. Mladenka, P., Macakova, K., Kujovska Krcmova, L., Javorska, L., Mrstna, K., Carazo, A., Protti, M., Remiao, F., Novakova, L., Vitamin K- sources, physiological role, kinetics, deficiency, detection, therapeutic use and toxicity, Nutrition Reviews, 2021, 80(4), 677-698, DOI: 10.1093/nutrit/nuab061

9. Dosedel, M., Jirkovsky, D., Macakova, K., Kujovska Krcmova, L., Javorska, L., Pourova, J., Mercolini, L., Remião, F., Novákova, L., Mladenka, P., Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination, Nutrients, 2021, 13(2), 615, 2-34.

2018

8. Pilka R., Neubert D., Stejskal D., Krejci G., Svestak M., Marek R., Adam T., Sobkova K., Ondrova D., Hambalek J., Maderka M., Solichova D., Kujovska Krcmova L., Javorska, L., Melichar B., Serum concentrations of TFF3, S100-A11 and AIF-1 in association with systemic inflammatory response, dinase stage and nodal involvement in endometrial cancer, Pteridines, 2018, 29 (1), 6-12

7. Dusek, T., Orhalmi, J., Sotona, O., Kujovska Krcmova, L., Javorska, L., Dolejs, J., Paral J., Neopterin, kynurenine and tryptofan as a new biomarkers for early detection of rectal anastomotic leakage, Videosurgery And Other Miniinvasive Techniques, 2018, 13 (1), 44-52

2017

6. Mergancova, J., Javorska, L., Siller, J., Sakra, L., Mergancova, J., Solichova, D., Kujovska Krcmova, L., Melichar, B., Mohelnikova-Duchonova, B., Studentova, H., Klos, D., Concentrations of neopterin, kynurenine and tryptofan in wound secretions of patients with breast cancer and malignant melanoma: a pilot study, Pteridines, 2017, 28 (3-4), 205-211

5. Melichar, B., Vitaskova, D., Bartouskova, M., Javorska, L., Kujovska Krcmova, L., Peskova, E., Hyspler, R., Solichova, D., Hruzova, K., Studentova, H., Comparison of performance of composite biomarkers of inflammatory response in determining the prognosis of breast cancer patients, Pteridines, 2017, 28 (3-4), 213-220

4. Melichar, B., Hruzova, K., Kujovska Krcmova, L., Javorska, L., Peskova, E., Solichova, D., Hyspler, R., Malirova, E., Vosmik, M., Bartouskova, M., Klos, D., Studentova, H., Association of peripheral blood cell count-derived ratios, biomarkers of inlfammatory response and tumor growth with outcome in previously treated metastatic colorectal carcinoma patients receiving cetuximab, Pteridines, 2017, 28 (3-4), 221-232

3. Javorska, L., Kujovska Krcmova, L., Solich, P., Kaska, M., Simple and rapid quantification of vancomycin in serum, urine and peritoneal/pleural effusion via UHPLC-MS/MS applicable to personalized antibiotik dosing, Journal Of Pharmaceutical And Biomedical Analysis, 2017, 142, 59-65

2. Melichar, B., Spisarova, M., Bartouskova, M., Kujovska Krcmova, L., Javorska, L., Studentova, H. Neopterin as a biomarker of imine response in cancer patiens, Annals Of Translational Medicine, 2017, 5 (13), a. n. 280

2016

1. Javorska, L., Kujovska Krcmova, L., Solichova, D., Solich, P., Kaska, M., Modern methods for vancomycin determination in biological fluids by HPLC based methods – A review, Journal Of Separation Science, 2016, 39 (1), 6-20

Intership:

05/2015 

University of Las Palmas de Gran Canaria, Spain - 1 week

06/2014 

Stockholm University, Sweden -  4 weeks