SCIENTIFIC RESEARCHER

PharmDr. Kristýna MRŠTNÁ, Ph.D.

Employment:

Research laboratory at Department of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove

Working position:

Research staff

Education and qualification:

2024

Ph.D. graduation

2019 - 2024

Doctoral studies in Bioanalytical Methods at the Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic

Doctoral thesis: Development of modern chromatographic methods for clinical research

2020

Completion of the state rigorous examination in the subject Pharmaceutical Analysis, obtaining the title of PharmDr., Charles University, Faculty of Pharmacy in Hradec Králové, Czech Republic

2019

Obtaining a specialization in the field of Pharmaceutical Analysis, Charles University, Faculty of Pharmacy in Hradec Králové, Czech Republic

Diploma thesis defense, degree Mgr., Charles University, Faculty of Pharmacy in Hradec Králové, Czech Republic

Diploma thesis: Development and validation of UHPLC method for determination of miconazole, econazole and its impurities in solid dispersions

State examination in Pharmacy, Charles University, Faculty of Pharmacy in Hradec Králové, Czech Republic

2014

Graduation from the grammar school in Ostrov, Czech Republic

Research focus:

Development of modern chromatographic methods (HPLC, UHPLC), sample preparation, biological matrices

Grant Projects:

2021

Grant of the Internal Competition of the University Hospital in Hradec Králové - Prognostic markers in the monitoring of non-infectious complications of patients with common variable immunodeficiency

- member of the research team

The Charles University Grant Agency (GA UK) - Modern preanalysis as a tool for solving complications in the determination of vitamin K

- project leader

Total publications: 7

Publications:

2024

7. Mrstna, K., Kujovska Krcmova, L., Suwanvecho, Ch., Jandova, M., Kovarikova, E., Strohalm, J., Hyspler, R., Solichova, D., Svec, F. α-Tocopherol and retinol content in Holder pasteurized versus high-pressure processed human milk during 6 months of storage, Journal of Food Composition and Analysis, 2024, 106421, DOI: 10.1016/j.jfca.2024.106421

6. Mrstna, K., Turonova, D., Suwanvecho, Ch., Svec, F., Kujovska Krcmova, L., The power of modern extraction techniques: A breakthrough in vitamin K extraction from human serum, Microchemical Journal, 2024, 198, 110170, DOI: 10.1016/j.microc.2024.110170

5. Ogadah, Ch.U., Mrstna, K., Matysova, L., Mullertz, A., Rades, T., Niederquell, A., Sklubalova, Z., Vranikova, B., Comparison of the liquisolid technique and co-milling for loading of a poorly soluble drug in inorganic porous excipients, International Journal of Pharmaceutics, 2024, 650, 123702, DOI: 10.1016/j.ijpharm.2023.123702

4. Mrstna, K., Matousova, K., Kujovska Krcmova, L., Carazo, A., Pourova, J., Mladenka, P., Matysova, L., Svec, F., Analysis of vitamin K1 and major K2 variants in rat/human serum and lipoprotein fractions by a rapid, simple, and sensitive UHPLC-MS/MS method, Journal of Chromatography A, 2024, 464548, DOI: 10.1016/j.chroma.2023.464548

2023

3. Mrstna, K., Kujovska Krcmova, L., Svec, F., Advances in kynurenine analysis, Clinica Chimica Acta, 2023, 547, 117441, DOI: 10.1016/j.cca.2023.117441

2. Mrstna, K., Matousova, K., Matous, P., Matysova, L., Svec, F., Snejdrova, E., Kujovska Krcmova, L., Analysis of terbinafine in PLGA-based drug delivery systems by a fast and sensitive UHPLC-DAD method, Analytical Methods, 2023, 15, 2823-2832 , DOI: 10.1039/D3AY00506B

2021

1. Mladenka, P., Macakova, K., Kujovska Krcmova, L., Javorska, L., Mrstna, K., Carazo, A., Protti, M., Remiao, F., Novakova, L., Vitamin K- sources, physiological role, kinetics, deficiency, detection, therapeutic use and toxicity, Nutrition Reviews, 2021, 80(4), 677-698, DOI: 10.1093/nutrit/nuab061

Conferences:

2023

12th Aegean Analytical Chemistry Days, Istanbul, Turkey

2022

26th International Symposium on Separation Sciences, Ljubljana, Slovenia

2021

5th International Caparica Christmas Conference on Sample Treatment 2021, Caparica, Portugal

Prague Meeting on Historical Perspectives of Mass Spectrometry, Prague, Czech Republic

11th Postgraduate and Postdoc Conference in Hradec Králové, Czech Republic

2020

Conference: 21st School of Mass Spectrometry in Srní, Czech Republic

10th Postgraduate and Postdoc Conference in Hradec Králové, Czech Republic